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<\/p>\n\n\n\n

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\"\"<\/figure>\n\n\n\n
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<\/p>\n\n\n\n

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    \u3053\u308c\u304c\u51e6\u7406\u901f\u5ea6\u306e\u5411\u4e0a\u3067\u3059\u3002



    \u6559\u79d1\u66f8\u306e\u4ee3\u8b1d\u7d4c\u8def\u306e\u30da\u30fc\u30b8\u3092\u958b\u3044\u3066\u3001



    \u672c\u3092\u9589\u3058\u3066\u304b\u3089
    \u767d\u7d19\u306b\u63cf\u3044\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002



    \u63cf\u3051\u306a\u304b\u3063\u305f\u90e8\u5206\u304c
    \u300c\u5206\u304b\u3063\u305f\u3064\u3082\u308a\u3067\u5206\u304b\u3063\u3066\u3044\u306a\u3044\u77e5\u8b58\u300d\u3067\u3059\u3002



    \u305d\u3053\u3060\u3051\u3092\u6559\u79d1\u66f8\u306b\u623b\u3063\u3066\u78ba\u8a8d\u3059\u308b\u3002



    \u3053\u308c\u3092\u7e70\u308a\u8fd4\u3059\u3060\u3051\u3067\u3001
    \u751f\u7269\u306e\u7406\u89e3\u306f\u6839\u672c\u304b\u3089\u5909\u308f\u308a\u307e\u3059\u3002


    <\/p>\n\n\n\n

    \n\n\n\n

    \u85ac\u7406\u306e\u8a18\u8ff0\u5bfe\u7b56\uff1a\u300c\u56e0\u679c\u306e\u968e\u6bb5\u300d\u3067\u6697\u8a18\u3092\u6368\u3066\u308b<\/h1>\n\n\n\n

    <\/p>\n\n\n\n



    \u85ac\u7406\u306e\u8a18\u8ff0\u5bfe\u7b56\u3067
    \u6700\u3082\u52b9\u679c\u304c\u3042\u3063\u305f\u306e\u306f\u3001



    \u300c\u6697\u8a18\u3092\u6368\u3066\u3066\u56e0\u679c\u306e\u968e\u6bb5\u3067\u7406\u89e3\u3059\u308b\u300d
    \u3053\u3068\u3067\u3057\u305f\u3002



    \u5f93\u6765\u306e\u85ac\u7406\u306e\u52c9\u5f37\u306f



    \u300c\u3053\u306e\u85ac\u306f\u03b2\u53d7\u5bb9\u4f53\u906e\u65ad\u85ac\u300d
    \u300c\u526f\u4f5c\u7528\u306f\u5f90\u8108\u300d\u3068\u3044\u3046\u77e5\u8b58\u306e



    \u70b9\u3068\u70b9\u3092\u899a\u3048\u308b\u30b9\u30bf\u30a4\u30eb\u3067\u3059\u3002



    \u3053\u308c\u3067\u56fd\u8a66\u306e\u9078\u629e\u80a2\u306f\u9078\u3079\u307e\u3059\u3002
    \u3067\u3082\u8a18\u8ff0\u3067\u306f\u901a\u7528\u3057\u307e\u305b\u3093\u3002



    \u8a18\u8ff0\u3067\u6c42\u3081\u3089\u308c\u308b\u306e\u306f
    \u6b21\u306e\u6d41\u308c\u3067\u3059\u3002



    \u75be\u60a3\u306e\u75c5\u614b

    \u2193\uff08\u306a\u305c\u3053\u306e\u75be\u60a3\u304c\u8d77\u304d\u308b\u306e\u304b\uff09

    \u85ac\u306e\u6a19\u7684\uff08\u53d7\u5bb9\u4f53\u30fb\u9175\u7d20\u30fb\u30c1\u30e3\u30cd\u30eb\u306a\u3069\uff09

    \u2193\uff08\u85ac\u306f\u3053\u3053\u306b\u3069\u3046\u4f5c\u7528\u3059\u308b\u306e\u304b\uff09

    \u4e3b\u4f5c\u7528\uff08\u85ac\u7406\u4f5c\u7528\uff09

    \u2193\uff08\u306a\u305c\u305d\u306e\u4f5c\u7528\u304c\u6cbb\u7642\u306b\u7e4b\u304c\u308b\u306e\u304b\uff09

    \u75c5\u614b\u3078\u306e\u52b9\u679c\uff08\u306a\u305c\u6cbb\u308b\u306e\u304b\uff09

    \u2193\uff08\u3053\u306e\u85ac\u7406\u4f5c\u7528\u306e\u88cf\u306b\u3042\u308b\u554f\u984c\u306f\uff09

    \u526f\u4f5c\u7528\uff08\u306a\u305c\u305d\u306e\u526f\u4f5c\u7528\u304c\u8d77\u304d\u308b\u306e\u304b\uff09<\/p>\n\n\n\n




    \u3053\u306e\u300c\u56e0\u679c\u306e\u968e\u6bb5\u300d\u3092
    \u4e00\u672c\u306e\u6d41\u308c\u3068\u3057\u3066\u66f8\u3051\u308b\u304b\u3069\u3046\u304b\u304c\u3001



    \u8a18\u8ff0\u306e\u5f97\u70b9\u3092\u6c7a\u3081\u307e\u3059\u3002



    \u79c1\u304c\u3084\u3063\u3066\u3044\u305f\u306e\u306f\u3001



    \u52c9\u5f37\u3057\u305f\u85ac\u3092\u4e00\u3064\u53d6\u308a\u4e0a\u3052\u3066
    \u300c\u3053\u306e\u85ac\u3092\u77e5\u3089\u306a\u3044\u4eba\u306b3\u5206\u3067\u8aac\u660e\u3059\u308b\u306a\u3089\uff1f\u300d
    \u3068\u81ea\u554f\u3057\u3066\u3001



    \u4e0a\u306e\u6d41\u308c\u306b\u6cbf\u3063\u3066
    \u58f0\u306b\u51fa\u3057\u3066\u8aac\u660e\u3059\u308b\u3053\u3068\u3067\u3059\u3002



    \u8aac\u660e\u3067\u304d\u306a\u304b\u3063\u305f\u90e8\u5206\u304c\u3001
    \u81ea\u5206\u306e\u7406\u89e3\u306e\u7a74\u3067\u3059\u3002



    \u3053\u306e\u7df4\u7fd2\u306e\u526f\u7523\u7269\u3068\u3057\u3066\u3001<\/strong>
    \u56fd\u8a66\u306e\u85ac\u7406\u554f\u984c\u304c<\/strong>



    \u300c\u3069\u306e\u9078\u629e\u80a2\u304c\u56e0\u679c\u3068\u3057\u3066\u6b63\u3057\u3044\u304b\u300d<\/strong>
    \u3092\u8003\u3048\u308b\u3060\u3051\u3067\u89e3\u3051\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/strong>



    \u6697\u8a18\u306e\u91cf\u3092\u5897\u3084\u3059\u306e\u3067\u306f\u306a\u304f\u3001
    \u7406\u89e3\u306e\u6df1\u3055\u3092\u5897\u3084\u3059\u3053\u3068\u304c\u3001



    \u6700\u7d42\u7684\u306b\u6697\u8a18\u3088\u308a\u3082\u5f37\u304f\u306a\u308a\u307e\u3059\u3002



    \u4eca\u65e5\u52c9\u5f37\u3057\u305f\u85ac\u3092\u4e00\u3064\u3060\u3051\u9078\u3093\u3067\u3001



    \u300c\u75be\u60a3\u306e\u75c5\u614b\u2192\u85ac\u306e\u6a19\u7684\u2192\u4e3b\u4f5c\u7528\u2192\u526f\u4f5c\u7528\u300d
    \u3092\u767d\u7d19\u306b\u66f8\u3044\u3066\u307f\u3066\u304f\u3060\u3055\u3044\u3002



    \u5168\u90e8\u66f8\u3051\u305f\u85ac\u306f
    \u300c\u672c\u5f53\u306b\u7406\u89e3\u3057\u305f\u85ac\u300d\u3067\u3059\u3002



    \u66f8\u3051\u306a\u304b\u3063\u305f\u90e8\u5206\u3060\u3051\u6559\u79d1\u66f8\u306b\u623b\u308b\u3002



    \u3053\u306e1\u85ac1\u7fd2\u6163\u304c\u3001
    \u85ac\u7406\u306e\u7406\u89e3\u3092\u6839\u672c\u304b\u3089\u5909\u3048\u307e\u3059\u3002


    <\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n
    \n\n\n\n

    \u75c5\u9662\u5c31\u6d3b\u306e\u7b46\u8a18\u5bfe\u7b56\u304c\u300c\u6700\u5f37\u306e\u63a5\u7740\u5264\u300d\u306b\u306a\u3063\u305f\u7406\u7531<\/h1>\n\n\n\n




    \u79c1\u306f4\u6708\u306b\u75c5\u9662\u5c31\u8077\u8a66\u9a13\u304c\u3042\u308a\u3001



    \u85ac\u5264\uff08ADME\u30fb\u85ac\u7269\u901f\u5ea6\u8ad6\uff09\u3092
    \u96c6\u4e2d\u7684\u306b\u56fa\u3081\u307e\u3057\u305f\u3002



    \u3053\u308c\u304c\u4e88\u60f3\u5916\u306e\u52b9\u679c\u3092\u751f\u307f\u307e\u3057\u305f\u3002



    \u85ac\u5264\uff08\u85ac\u7269\u52d5\u614b\uff09\u306f\u3001
    \u751f\u7269\uff08\u4ee3\u8b1d\u7d4c\u8def\u30fb\u9175\u7d20\uff09\u3068
    \u85ac\u7406\uff08\u4f5c\u7528\u6a5f\u5e8f\u30fb\u526f\u4f5c\u7528\uff09\u306e\u4e21\u65b9\u3068



    \u6df1\u304f\u95a2\u9023\u3057\u3066\u3044\u307e\u3059\u3002



    \u4f8b\u3048\u3070



    \u300cCYP3A4\u3067\u4ee3\u8b1d\u3055\u308c\u308b\u85ac\u3068
    CYP\u963b\u5bb3\u85ac\u306e\u7d44\u307f\u5408\u308f\u305b\u306b\u3088\u308b\u76f8\u4e92\u4f5c\u7528\u300d\u306f\u3001



    \u751f\u7269\uff08\u4ee3\u8b1d\u9175\u7d20\u306e\u4ed5\u7d44\u307f\uff09
    \u30fb\u85ac\u7406\uff08\u85ac\u7269\u76f8\u4e92\u4f5c\u7528\uff09
    \u30fb\u85ac\u5264\uff08\u8840\u4e2d\u6fc3\u5ea6\u3078\u306e\u5f71\u97ff\uff09\u304c



    \u4e00\u672c\u306e\u56e0\u679c\u3067\u7e4b\u304c\u308a\u307e\u3059\u3002



    \u751f\u7269\u3068\u85ac\u7406\u306e\u8a18\u8ff0\u5bfe\u7b56\u3067
    \u300c\u56e0\u679c\u306e\u6d41\u308c\u300d\u3092\u7406\u89e3\u3057\u3066\u3044\u305f\u3053\u3068\u3067\u3001



    \u85ac\u5264\u306e\u7406\u89e3\u304c\u3053\u308c\u307e\u3067\u306b\u306a\u304f
    \u901f\u304f\u9032\u307f\u307e\u3057\u305f\u3002



    \u305d\u3057\u3066\u85ac\u5264\u306e\u7406\u89e3\u304c\u6df1\u307e\u308b\u3053\u3068\u3067\u3001
    \u751f\u7269\u3068\u85ac\u7406\u306e\u77e5\u8b58\u304c\u3055\u3089\u306b



    \u5f37\u56fa\u306b\u7e4b\u304c\u308a\u307e\u3057\u305f\u3002



    \u8a18\u8ff0\uff08\u751f\u7269\u30fb\u85ac\u7406\uff09<\/strong>
    \u2192 \u85ac\u5264\uff08\u85ac\u7269\u52d5\u614b\uff09\u2192 \u56fd\u8a66\u904e\u53bb\u554f<\/strong>



    \u3068\u3044\u3046\u9806\u756a\u3067\u7406\u89e3\u304c\u7a4d\u307f\u91cd\u306a\u308b\u3068\u3001<\/strong>



    \u56fd\u8a66\u306e\u554f\u984c\u304c<\/strong>
    \u300c\u5168\u90e8\u7e4b\u304c\u3063\u3066\u3044\u308b\u554f\u984c\u7fa4\u300d\u3068\u3057\u3066<\/strong>



    \u898b\u3048\u308b\u3088\u3046\u306b\u306a\u308a\u307e\u3059\u3002<\/strong>



    \u3053\u308c\u304c
    \u300c\u5168\u90e8\u306f\u5206\u304b\u3089\u306a\u3044\u3051\u3069\u3001\u5168\u4f53\u306f\u8aad\u3081\u308b\u300d
    \u3068\u3044\u3046\u611f\u899a\u306e\u6b63\u4f53\u3067\u3059\u3002



    <\/p>\n\n\n\n

    \n\n\n\n

    \u56fd\u8a66\u306b\u9593\u306b\u5408\u308f\u305b\u308b\u305f\u3081\u306e\u300c\u66f8\u3044\u3066\u2192\u6d41\u3057\u3066\u2192\u623b\u308b\u300d\u30eb\u30fc\u30d7<\/h1>\n\n\n\n




    \u8a18\u8ff0\u5bfe\u7b56\u3068\u85ac\u5264\u306e\u7406\u89e3\u3092
    \u7a4d\u307f\u91cd\u306d\u305f\u5f8c\u3001



    \u56fd\u8a66\u904e\u53bb\u554f\u306b\u623b\u3063\u305f\u3068\u304d\u306e
    \u52c9\u5f37\u30eb\u30fc\u30d7\u306f\u30b7\u30f3\u30d7\u30eb\u3067\u3059\u3002



    \u2460 \u904e\u53bb\u554f\u3092\u300c\u6d41\u3057\u300d\u30671\u5468\u3059\u308b<\/strong>
    \u3000\u2192\u899a\u3048\u3088\u3046\u3068\u3057\u306a\u3044\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002



    \u3000\u300c\u3069\u3093\u306a\u554f\u984c\u304c\u51fa\u308b\u304b\u30fb\u81ea\u5206\u306f\u3069\u3053\u3067\u8a70\u307e\u308b\u304b\u300d
    \u3000\u3092\u628a\u63e1\u3059\u308b\u3053\u3068\u3060\u3051\u304c\u76ee\u7684\u3067\u3059\u3002



    \u2461 \u5206\u304b\u3089\u306a\u304b\u3063\u305f\u554f\u984c\u3060\u3051\u9752\u672c\u306b\u623b\u308b<\/strong>
    \u3000\u2192\u5168\u90e8\u3084\u308a\u76f4\u305d\u3046\u3068\u3057\u306a\u3044\u3053\u3068\u304c\u5927\u5207\u3067\u3059\u3002



    \u3000\u300c\u306a\u305c\u3053\u306e\u9078\u629e\u80a2\u304c\u6b63\u3057\u3044\u306e\u304b\u300d\u304c
    \u3000\u5206\u304b\u3089\u306a\u304b\u3063\u305f\u554f\u984c\u3060\u3051\u3001



    \u3000\u6559\u79d1\u66f8\u3067\u78ba\u8a8d\u3057\u307e\u3059\u3002



    \u2462 \u85ac\u30bc\u30df\u8b1b\u7fa9\u3067\u7a74\u3092\u57cb\u3081\u308b<\/strong>



    \u81ea\u5206\u3060\u3051\u3067\u306f\u6c17\u3065\u3051\u306a\u304b\u3063\u305f
    \u300c\u91cd\u8981\u30dd\u30a4\u30f3\u30c8\u306e\u629c\u3051\u300d\u3092
    \u8b1b\u7fa9\u3067\u88dc\u5f37\u3057\u307e\u3059\u3002



    \u2463 \u2460~\u2462\u30922\u301c3\u5468\u7e70\u308a\u8fd4\u3059<\/strong>



    \u300c\u7406\u89e3\u306e\u7b4b\u529b\u300d\u304c\u3042\u308b\u72b6\u614b\u3067
    \u3053\u306e\u30eb\u30fc\u30d7\u306b\u5165\u308b\u3068\u3001



    \u4e00\u5468\u3054\u3068\u306b\u300c\u8aad\u3081\u308b\u554f\u984c\u306e\u5272\u5408\u300d\u304c
    \u5897\u3048\u3066\u3044\u304d\u307e\u3059\u3002



    \u7126\u3063\u3066\u8a70\u3081\u8fbc\u307e\u306a\u304f\u3066\u3082\u3001
    \u7406\u89e3\u304c\u7a4d\u307f\u4e0a\u304c\u308b\u611f\u899a\u304c\u6301\u3066\u307e\u3059\u3002


    <\/p>\n\n\n\n

    \n\n\n\n

    \u300c\u81ea\u5206\u306e\u5f37\u307f\u00d7\u66f8\u3044\u3066\u53ef\u8996\u5316\u3059\u308b\u300d\u304c\u3001\u8ab0\u3067\u3082\u4f7f\u3048\u308b\u552f\u4e00\u306e\u6cd5\u5247<\/h1>\n\n\n\n




    \u8a18\u8ff0\u5bfe\u7b56\u304c\u56fd\u8a66\u306b\u52b9\u304f\u7406\u7531\u306f\u3001



    \u7279\u5b9a\u306e\u79d1\u76ee\u304c\u300c\u6b63\u89e3\u300d\u3060\u304b\u3089
    \u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002



    \u300c\u8aac\u660e\u3067\u304d\u308b\u7406\u89e3\u300d\u3092\u4f5c\u308b<\/strong>
    \u30d7\u30ed\u30bb\u30b9\u305d\u306e\u3082\u306e\u304c\u3001<\/strong>



    \u56fd\u8a66\u306e\u51e6\u7406\u901f\u5ea6\u3068\u6b63\u7b54\u7387\u3092<\/strong>
    \u4e0a\u3052\u308b\u304b\u3089\u3067\u3059\u3002<\/strong>



    \u751f\u7269\u304c\u5f97\u610f\u306a\u3089\u751f\u7269\u306e\u8a18\u8ff0\u3067
    \u4ee3\u8b1d\u7d4c\u8def\u3092\u5168\u90e8\u63cf\u304f\u3002



    \u85ac\u7406\u304c\u5f97\u610f\u306a\u3089\u85ac\u7406\u306e\u8a18\u8ff0\u3067
    \u56e0\u679c\u306e\u968e\u6bb5\u3092\u5168\u90e8\u66f8\u304f\u3002



    \u6709\u6a5f\u5316\u5b66\u304c\u5f97\u610f\u306a\u3089\u6709\u6a5f\u5316\u5b66\u306e\u8a18\u8ff0\u3067
    \u53cd\u5fdc\u6a5f\u69cb\u3092\u5168\u90e8\u66f8\u304f\u3002



    \u3069\u306e\u79d1\u76ee\u3067\u3082\u69cb\u3044\u307e\u305b\u3093\u3002



    \u5927\u5207\u306a\u306e\u306f\u3001



    \u300c\u66f8\u3044\u3066\u53ef\u8996\u5316\u3059\u308b\u3053\u3068\u300d
    \u300c\u56e0\u679c\u306e\u6d41\u308c\u3067\u7406\u89e3\u3059\u308b\u3053\u3068\u300d
    \u300c\u58f0\u306b\u51fa\u3057\u3066\u8aac\u660e\u3067\u304d\u308b\u307e\u3067\u3084\u308b\u3053\u3068\u300d



    \u306e3\u3064\u3060\u3051\u3067\u3059\u3002



    \u3053\u306e3\u3064\u3092\u5b9f\u8df5\u3057\u305f\u4eba\u3060\u3051\u304c\u3001<\/strong>



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    <\/p>\n\n\n\n

    \"\"<\/figure>\n\n\n\n
    \n\n\n\n




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    \n

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